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UAMC-3203
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UAMC-3203图片
规格:98%
分子量:471.7
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
UAMC-3203 是一种有效的选择性铁死亡抑制剂,IC50 为 12 nM。
货号:ajcx17520
CAS:2271358-64-4
分子式:C25H37N5O2S
分子量:471.7
溶解度:Ethanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells. It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 . In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.