3'-Hydroxy Repaglinide

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	5mg
规格:	98%
市场价:	24696元
分子量:	468.59

产品介绍

3'-Hydroxy Repaglinide 是 Repaglinide 的主要 CYP2C8 代谢产物。Repaglinide 是氨基甲酰甲基苯甲酸 (CMBA) 衍生物，可作用于 II 型糖尿病。
货号:ajcx16958
CAS:874908-14-2
分子式:C27H36N2O5
分子量：468.59
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes[1][2].

[1]. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probedrugs and their corresponding metabolites in human serum and urine. Anal Bioanal Chem. 2017 Jan;409(1):251-268. [2]. Honkalammi J, et al. Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans. Clin Pharmacol Ther. 2011 Apr;89(4):579-86.