Dihydrokaempferol 是从紫荆花 Bauhinia championii (Benth) 中分离得到的。 Dihydrokaempferol 诱导 apoptosis 并抑制 Bcl-2 和 Bcl-xL 的表达。Dihydrokaempferol 可以作为抗关节炎新药的良好候选。
货号:ajcx15066
CAS:480-20-6
分子式:C15H12O6
分子量：288.25
溶解度:DMSO: 10 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].

Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1].Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1].Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells

[1]. Zhang Y, et al. Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes. Evid Based Complement Alternat Med. 2018 Dec 2;2018:9806160.