GsMTx4 TFA 是一种蜘蛛毒液肽，选择性地抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道 (MSCs)。GsMTx4 TFA 是一种重要的药理学工具，用于鉴定兴奋性 MSCs 在正常生理学和病理学中的作用。GsMTx4 TFA 显着减弱膀胱机能亢进。
货号:ajcx14820
CAS:N/A
分子式:C187H280N49F3O47S6
分子量：4215.91
溶解度:H2O: 16.67 mg/mL (3.95 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GsMTx4 TFA is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1]. GsMTx4 TFA significantly attenuates bladder hyperactivity[2].

[1]. Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45. [2]. Liu Q, et al. Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. Exp Mol Med. 2018 May 7;50(5):60.