| 规格: | 98% |
| 分子量: | 389.52 |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
Background:
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.
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