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CBR-470-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CBR-470-1图片
规格:98%
分子量:365.90
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
CBR-470-1 是糖酵解磷酸甘油酸激酶1 (PGK1) 的抑制剂。 CBR-470-1 也是一种非共价的?Nrf2?激活剂。CBR-470-1 通过激活 Keap1-Nrf2 级联反应,保护 SH-SY5Y 神经元细胞免受 MPP+?诱导的细胞毒性。
货号:ajcx12134
CAS:2416095-06-0
分子式:C??H??ClNO?S?
分子量:365.90
溶解度:DMSO : 200 mg/mL (546.60 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CBR-470-1 is an inhibitor of the?glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent?Nrf2?activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2].

CBR-470-1 (0.01-10 μM; 24 h) has an EC50?of 962 nM in ARE-LUC reporter assay of IMR32 cells[1].
CBR-470-1 (0.5-20 μM; 1-24 h) results in a dose- and time-dependent accumulation of Nrf2 protein in IMR32 cells[1].
CBR-470-1 (10 μM; 4 h) activates Nrf2 signaling cascade in SH-SY5Y cells[2].
CBR-470-1 (10 μM; 2 h) inhibits MPP+-induced oxidative injury in SH-SY5Y neuronal cells[2].

Western Blot Analysis[1]

Cell Line:IMR32 cells
Concentration:0.5, 1, 5, 10, 20 μM
Incubation Time:1, 2, 4, 8, 24 h
Result:Increased the Nrf2 protein in a dose- and time-dependent manner.
Increased both mRNA and protein levels of the Nrf2-responsive genes?NQO1?and?HMOX1.