AXC-715 (T785) trihydrochloride 是一种 TLR7/TLR8 双激动剂，从专利 WO2020168017 A1 中获得。AXC-715 trihydrochloride 可用于合成抗体佐剂免疫偶联物，偶联物包括一个与程序性死亡配体 1 (PD-L1) 连接到一个或多个佐剂的抗体结构上。
货号:ajcx39278
CAS:2479276-17-8
分子式:C18H28Cl3N5
分子量：420.81
溶解度:DMSO : 125 mg/mL (297.05 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1[1]. AXC-715 trihydrochloride, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2].

[1]. Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. Patent WO2020168017A1.
[2]. Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. Patent WO2020190734A1.