APX2039 是一种口服有效的真菌 Gwt1 酶 (fungal Gwt1 enzyme) 抑制剂。APX2039 对 C. neoformans 和 C. gattii 具有极强的抗氪球菌活性。APX2039 阻断 GPI (糖基磷脂酰肌醇)锚定细胞壁甘露蛋白的定位。APX2039 可用于隐球菌脑膜炎 (CM) 的研究。
货号:ajcx38416
CAS:2342606-49-7
分子式:C20H15FN4O2
分子量：362.36
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research[1][2].

[1]. Karen J Shaw, et al. 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis. Open Forum Infect Dis. 2020 Dec 31.
[2]. Yu CH, et al. Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. mBio. 2021 Dec 21;12(6):e0231321.