SP4206 是一种 IL-2/IL-2Rα 相互作用抑制剂，SP4206 高亲和力结合到 IL-2 (Kd=70 nM) ，且阻断 IL-2 与其受体 IL-2Rα 结合 (Kd=10 nM)。
货号:ajcx37702
CAS:515846-21-6
分子式:C30H37Cl2N7O6
分子量：662.56
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM)[1].

SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC50s of 68.8, 80.1, 117.0, and 10.4 nM, respectively[1].

[1]. Thanos CD, et al. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7.