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8-Chloro-cAMP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
8-Chloro-cAMP图片
包装:5mg
规格:98%
市场价:12171元
分子量:363.65

产品介绍
8-Chloro-cAMP 是一种 cAMP 类似物,可诱导生长停滞,并调节 cAMP 依赖性 PKA 活性。8-Chloro-cAMP 具有抗癌活性。
货号:ajcx37658
CAS:41941-56-4
分子式:C10H11ClN5O6P
分子量:363.65
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1].

8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1].

In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1].

[1]. C Indolfi, et al. 8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo. J Am Coll Cardiol. 2000 Jul;36(1):288-93.