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Estrone-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estrone-d4图片
包装:5mg
规格:98%
市场价:9922元
分子量:274.39

产品介绍
Estrone-d4 (E1-d4) 是一种氘代标记的 Estrone。Estrone (E1) 是一种天然的雌激素。Estrone 是内源性雌激素的主要代表,由多种组织产生,尤其是脂肪组织。Estrone 是脂肪细胞中雄烯二酮芳构化过程的结果。
货号:ajcx37612
CAS:53866-34-5
分子式:C18H18D4O2
分子量:274.39
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Estrone-d4 (E1-d4) is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45(11):3341-3350.
[3]. de Padua Mansur A, et al. Long-term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease. ScientificWorldJournal. 2012;2012:363595.