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Cedirogant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cedirogant图片
规格:98%
分子量:547.78
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Cedirogant (ABBV-157) 是一种具有口服活性 RORγt 反向激动剂,可用于银屑病的研究。
货号:ajcx35720
CAS:2055496-11-0
分子式:C24H20Cl3F3N2O3
分子量:547.78
溶解度:DMSO : 250 mg/mL (456.39 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant can be used for psoriasis research[1][2].

The transcription factor retinoic acid-related orphan receptor gamma t (RORγt) has been identified as the master regulator of TH17 cell differentiation and IL-17/22 production and is therefore an attractive target for the treatment of inflammatory diseases. Cedirogant (ABBV-157) has the potential for chronic plaque psoriasis research[1].

[1]. Elena Campione, et al. Experimental Pharmacological Management of Psoriasis. J Exp Pharmacol. 2021 Jul 26;13:725-737.
[2]. Christian Gege. Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases - where are we presently• Expert Opin Drug Discov. 2021 Jul 7;1-19.