dBET23 是一种高效、选择性的 PROTAC BRD4 降解剂，对 BRD4BD1 蛋白的 DC50/5h 约为 50 nM。
货号:ajcx35694
CAS:1957234-83-1
分子式:C43H45ClN8O9S
分子量：885.38
溶解度:DMSO : 170 mg/mL (192.01 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein[1].

dBET23 occupies the canonical binding sites on CRBN and BRD4BD1 for thalidomide and JQ1, respectively[1].

[1]. Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018;14(7):706-714.