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LTA4H-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LTA4H-IN-1图片
规格:98%
分子量:392.77
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
LTA4H-IN-1 是一种有效的白三烯 A4 水解酶 LTA4H 抑制剂,IC50 值为 2 nM。LTA4H-IN-1 可用于研究炎症和自身免疫性疾病。详细信息请参考专利文献 WO2015092740A1 中的化合物 29。
货号:ajcx35674
CAS:1799681-85-8
分子式:C16H14ClFN6O3
分子量:392.77
溶解度:DMSO : 250 mg/mL (636.50 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders[1].

LTA4H-IN-1 (15 min) inhibits the hydrolysis of 7-amino-4-methylcoumarin (AMC) derivative of Arginine (Arg-AMC) which is catalyzed by LTA4H, with an IC50 of 2 nM[1].LTA4H-IN-1 (30 min) inhibits LTB4 biosynthesis in a human whole blood assay (hWB), with an IC50 of 167 nM[1].

LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared with vehicle control in mice[1].

[1]. Bollbuck B, et, al. Heteroaryl butanoic acid derivatives as leukotriene A4 hydrolase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2015092740A1.