您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Fosciclopirox
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Fosciclopirox
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fosciclopirox图片
规格:98%
分子量:317.27
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Fosciclopirox 通过靶向 γ-分泌酶抑制尿路上皮癌的生长。静脉给药后。Fosciclopirox 选择性地将活性代谢物 Ciclopirox (CPX) 递送至整个尿路。Ciclopirox (CPX) 在许多实体和血液恶性肿瘤中显示出抗癌活性。
货号:ajcx35542
CAS:1380539-06-9
分子式:C13H20NO6P
分子量:317.27
溶解度:DMSO : 100 mg/mL (315.19 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract[1][2]. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.

[1]. Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. Cell Death Dis. 2021 May 31;12(6):562.
[2]. Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.