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TRPV4 agonist-1 free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TRPV4 agonist-1 free base图片
规格:98%
分子量:448.46
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
TRPV4 agonist-1 free base 是一种瞬时受体电位香草酸亚型 4 (TRPV4) 激动剂,在 hTRPV4 Ca2+ 实验中 EC50 为 60 nM。
货号:ajcx35300
CAS:2314467-59-7
分子式:C25H22F2N4O2
分子量:448.46
溶解度:DMSO : 83.33 mg/mL (185.81 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1].

[1]. Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.