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SM-1295
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SM-1295图片
规格:98%
分子量:598.53
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
SM-1295 是凋亡蛋白 IAP 的拮抗剂,其对 XIAP-BIR3、c-IAP1-BIR3 和 c-IAP2-BIR3 的 Kd 值分别为 3077 nM、3.2 nM 和 9.5 nM。
货号:ajcx35202
CAS:1562375-46-5
分子式:C29H36BrN5O4
分子量:598.53
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].

SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of 900-fold for cIAP1 over XIAP[1].SM-1295 (compound 5) exhibits an IC50 of 46 nM in MDA-MB-231[1].

[1]. Haiying Sun, et al. Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells. ACS Chem Biol. 2014 Apr 18;9(4):994-1002.
[2]. Hui Cong, et al. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. J Med Chem. 2019 Jun 27;62(12):5750-5772.