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PB2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PB2图片
规格:98%
分子量:286.11
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PB2 是一种 tris(2-carboxyethyl)phosphine (TCEP) 类似物,可在纳摩尔和皮摩尔浓度下增加体外 retinal ganglion (RGCs) 细胞的存活。PB2 比 TCEP 具有更强的渗透性。PB2 作为还原剂,对 RGCs 具有高度的神经保护作用。
货号:ajcx35092
CAS:914940-24-2
分子式:C16H20BO2P
分子量:286.11
溶解度:DMSO : 100 mg/mL (349.52 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs[1].

PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1].PB2 has modifications that neutralize the polarity of the compounds. The methylesters of PB2 is likely to be cleaved by cytosolic esterases, yielding a polar intracellular intermediate that would be unlikely to cross cell membranes[1].

[1]. Schlieve CR, et al. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells. Exp Eye Res. 2006;83(5):1252-1259.