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Mebeverine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mebeverine hydrochloride图片
规格:98%
分子量:466.01
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Mebeverine hydrochloride 是 β-苯乙胺的衍生物,一种增肌剂,可有效阻止肠道蠕动。Mebeverine hydrochloride直接阻断电压控制的钠通道 (voltage-operated sodium channels),抑制细胞内钙的积累。
货号:ajcx34948
CAS:2753-45-9
分子式:C25H36ClNO5
分子量:466.01
溶解度:DMSO : ≥ 155 mg/mL (332.61 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation[1][2].

Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity[2].

[1]. AnnahÁzi A, et al. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014;20(20):6031-6043. [2]. Den Hertog A, et al. Modification of alpha 1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Eur J Pharmacol. 1987 Jun 26;138(3):367-74.