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ELOVL6-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ELOVL6-IN-1图片
规格:98%
分子量:495.49
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
ELOVL6-IN-1 是一种有效的,具有口服活性和选择性 ELOVL6 抑制剂。ELOVL6-IN-1 对小鼠 ELOVL6 的抑制作用呈剂量依赖性,IC50 值为 0.350 μM。ELOVL6-IN-1 对丙二酰辅酶 a (Ki=994 nM) 和对棕榈酰辅酶 a 具有非竞争性抑制 ELOVL6 作用。
货号:ajcx34730
CAS:1185736-98-4
分子式:C27H24F3N3O3
分子量:495.49
溶解度:DMSO : 50 mg/mL (100.91 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].

ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1].ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].

[1]. Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256.