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Abeprazan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abeprazan图片
规格:98%
分子量:410.41
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Abeprazan (DWP14012) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan 是一种潜在的质子泵抑制剂,用于研究与酸相关的疾病。
货号:ajcx34482
CAS:1902954-60-2
分子式:C19H17F3N2O3S
分子量:410.41
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1].

The mechanism of action of Abeprazan is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1].

DWP14012 inhibited acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].

[1]. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.