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WNK-IN-11 D3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WNK-IN-11 D3图片
规格:98%
分子量:465.41
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
WNK-IN-11 D3 是一种具有口服活性、选择性和强效的 With-No-Lysine (WNK) 激酶抑制剂。WNK-IN-11 D3 有效调节心血管稳态。
货号:ajcx34168
CAS:2123483-49-6
分子式:C21H18D3Cl2N5OS
分子量:465.41
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis[1].

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].

[1]. Yamada K, Levell J, Yoon T, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017;60(16):7099-7107.