您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > RAS/RAS-RAF-IN-1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
RAS/RAS-RAF-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RAS/RAS-RAF-IN-1图片
规格:98%
分子量:807.98
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
RAS/RAS-RAF-IN-1 是有效的 RAS 和 RAS-RAF 抑制剂。RAS/RAS-RAF-IN-1 对于亲环蛋白 A (CYPA) 结合亲和力的 KD 值为 5.0 μM-15 μM。RAS/RAS-RAF-IN-1 具有抗肿瘤活性。
货号:ajcx33852
CAS:2447039-81-6
分子式:C45H57N7O7
分子量:807.98
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1].

RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1].

[1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.