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DS-7423
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DS-7423图片
规格:98%
分子量:520.51
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
DS-7423 是 PI3K 和 mTOR 的双抑制剂,其对 PI3Kα 和 mTOR 的IC50 值分别为15.6 nM 和 34.9 nM。DS-7423 具有抗癌活性。
货号:ajcx33834
CAS:1222104-37-1
分子式:C22H27F3N10O2
分子量:520.51
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].

DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2].

[1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42(7):757-62.
[2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220.