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Neriifolin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neriifolin图片
包装:5mg
规格:98%
市场价:3969元
分子量:534.68

产品介绍
Neriifolin是一种穿透中枢神经系统的强心苷,是一种Na+,K+-ATPase的抑制剂。Neriifolin可靶向beclin1,抑制LC3相关吞噬体的形成,改善实验性自身免疫性脑脊髓炎(EAE)的发展。Neriifolin诱导人肝癌HepG2细胞周期阻滞和凋亡。
货号:ajcx32138
CAS:466-07-9
分子式:C30H46O8
分子量:534.68
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins[1].


[1]. Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237. [2]. Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741.