您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Ceapin-A7
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Ceapin-A7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ceapin-A7图片
规格:98%
分子量:470.32
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Ceapin-A7是一种内质网应激ATF6α信号的选择性阻断剂,其IC50值为0.59μM。Ceapin-A7可用于探讨ATF6α促细胞活化的机制及其在病理环境中的作用。
货号:ajcx32096
CAS:2323027-38-7
分子式:C20H12F6N4O3
分子量:470.32
溶解度:DMSO: 100 mg/mL (212.62 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1].

Ceapin-A7 sensitizes cells to ER stress[1].Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β[1].


[1]. Ciara M Gallagher, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife. 2016; 5: e11878.