4-Hydroxyatomoxetine是Atomoxetine的活性代谢产物。4-Hydroxyatomoxetine通过细胞色素P4502D6(CYP2D6)酶代谢。Atomoxetine是去甲肾上腺素重吸收抑制剂，与人NET，SERT和DAT的放射性配体结合的Ki分别为5nM，77nM和1451nM。
货号:ajcx30032
CAS:435293-66-6
分子式:C17H21NO2
分子量：271.35
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1][2].

[1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children. [2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.