4-Hydroxy-2-methylbenzenesulfonicacidammonium是Policresulen的杂质。Policresulen是一种有效的NS2B/NS3蛋白酶抑制剂，IC50为0.48μg/mL。Policresulen有效抑制DENV2病毒在BHK-21细胞中的复制，IC50为4.99μg/mL。Policresulen是蛋白酶的竞争性抑制剂，并轻微影响蛋白酶的稳定性。
货号:ajcx29066
CAS:N/A
分子式:C7H11NO4S
分子量：205.23
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability[1].

[1]. Deng-wei Wu, et al. Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells. Acta Pharmacol Sin. 2015 Sep;36(9):1126-36.