(R)-DNMDP 是一种有效的选择性癌细胞杀伤剂。(R)-DNMDP，是 DNMDP 的 R 形式，直接结合 PDE3A。DNMDP 与 PDE3A 的结合促进了 PDE3A 与 Schlafen 12 (SLFN12) 之间的相互作用。
货号:ajcx29020
CAS:1630760-60-9
分子式:C15H20N4O3
分子量：304.34
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12)[1][2].

[1]. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. Nat Chem Biol. 2016 Feb;12(2):102-8. [2]. Luc DE WAAL, et al. Compositions and methods for cancer expressing pde3a or slfn12. WO2017027854A1.