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SAH-EZH2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SAH-EZH2图片
包装:500ug
规格:98%
市场价:7332元
分子量:3432.05

产品介绍
EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
货号:ajcx27782
CAS:1453222-26-8
分子式:C155H256N48O40
分子量:3432.05
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.


Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat.Chem.Biol. 9 643 PMID:23974116 |Kim et al (2015) SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat.Med. 21 1491 PMID:26552009