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dBRD9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
dBRD9图片
包装:5mg
规格:98%
市场价:5546元
分子量:856.75

产品介绍
Potent and selective BRD9 degrading PROTAC
货号:ajcx27716
CAS:2341840-98-8
分子式:C40H45N7O10.2HCl
分子量:856.75
溶解度:Water 17.14 mg/ml, DMSO 42.84 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PROTAC? composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.


Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626