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JNJ 39758979 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JNJ 39758979 dihydrochloride图片
规格:98%
分子量:294.22
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
High affinity and selective histamine H4 antagonist; orally bioavailable
货号:ajcx27500
CAS:N/A
分子式:C11H19N5.2HCl
分子量:294.22
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

High affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.


Thurmond et al (2014) Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID:24549371