High affinity and selective histamine H4 antagonist; orally bioavailable
货号:ajcx27500
CAS:N/A
分子式:C11H19N5.2HCl
分子量:294.22
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:
现货Background:
High affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.
Thurmond et al (2014) Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID:24549371