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SK 216
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SK 216图片
规格:98%
分子量:533.52
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Plasminogen activator inhibitor-1 (PAI-1) inhibitor
货号:ajcx27438
CAS:654080-03-2
分子式:C29H29NO6Na2
分子量:533.52
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.


Omori et al (2016) Inhibition of plasminogen activator inhibitor-1 attenuates transforming growth factor-β-dependent epithelial mesenchymal transition and differentiation of fibroblasts to myofibroblasts. PLoS One. 11 e0148969 PMID:26859294 |Takayama et al (2016) Inhibition of PAI-1 limits tumor angiogenesis regardless of angiogenic stimuli in malignant pleural mesothelioma. Cancer Res. 76 3285 PMID:27197170 |Masuda et al (2013) SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol.Cancer Ther. 12 2378 PMID:23990114