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AR-C 118925XX
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AR-C 118925XX图片
包装:5mg
规格:98%
市场价:4811元
分子量:537.59

产品介绍
Selective and competitive P2Y2 antagonist
货号:ajcx26886
CAS:216657-60-2
分子式:C28H23N7O3S
分子量:537.59
溶解度:53.76mg/mL in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Selective, competitive P2Y2 receptor antagonist. Inactive against a panel of 37 other receptors at a concentration of 10 μM. Inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).

参考文献:
Kemp et al (2004) Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. Am.J.Respir.Cell Mol.Biol. 31 446 PMID:15231488
Meghani (2002) The design of P2Y2 antagonists for the treatment of inflammatory diseases. Abstract of papers, 224th ACS National Meeting, Boston, MA
Rafehi et al (2017) Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925. Purinergic.Signal. 13 89 PMID:27766552