AZ-GHS-22 是一种有效的、非 CNS 渗透性 GHS-R1a 反向激动剂 (IC50=0.77 nM)。
货号:ajcx25604
CAS:1143020-91-0
分子式:C27H33ClN6O5S2
分子量：621.2
溶解度:0.1 M HCl: 25 mg/ml,DMSO: 50 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.¹It binds to GHS-R1a with an IC₅₀value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.

1.McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)