A stimulant laxative and prodrug form of desacetyl bisacodyl
货号:ajcx25588
CAS:1307301-38-7
分子式:C18H13NO8S2·2Na [H2O]
分子量：499.4
溶解度:: ,DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Picosulfate is a stimulant laxative and prodrug form of desacetyl bisacodyl .¹Unlike bisacodyl , picosulfate is hydrolyzed to DAB by colonic microbiota. Picosulfate (5 mg/kg) increases excreted fecal weight in a rat model of loperamide-induced constipation.²Formulations containing picosulfate have been used for colonoscopy preparation.

1.Twycross, R., Sykes, N., Mihalyo, M., et al.Stimulant laxatives and opioid-induced constipationJ. Pain Symptom Manage.43(2)306-313(2012) 2.MÉitÉ, S., Bahi, C., YÉo, D., et al.Laxative activities of Mareya micrantha (Benth.) MÜll. Arg. (Euphorbiaceae) leaf aqueous extract in ratsBMC Complement. Altern. Med.107(2010)