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Ungeremine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ungeremine图片
规格:98%
分子量:266.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A betaine-type alkaloid with diverse biological activities
货号:ajcx25578
CAS:2121-12-2
分子式:C16H12NO3
分子量:266.3
溶解度:Methanol: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ungeremine is a betaine-type alkaloid that has been found inC. zeylanicumand has diverse biological activities.1,2,3,4It is an inhibitor of acetylcholinesterase (AChE; IC50= 0.35 µM).2Ungeremine acts as a topoisomerase poison, inducing double-strand breaks in DNA by stabilizing the linkage between topoisomerase IIβ and DNA.3It inhibits the relaxation of supercoiled DNA by human topoisomerase I and -IIα andE. colitopoisomerase I and -IV (IC50s = 6.1, 25.8, 15, and 7.3 µM, respectively).4Ungeremine inhibits the growth of HL-60, MOLT-4, K562, U937, and LXFL 529L cells (IC50s = 1.3, 0.7, 0.8, 2.5, and 1.2 µM, respectively). It is cytotoxic to a variety of drug-sensitive and -resistant cancer cells (IC50s = 4.89-6.45 and 3.67-75.24 µM, respectively) and induces ferroptosis, necroptosis, apoptosis, and autophagy in CCRF-CEM leukemia cells. Ungeremine (60 mg/kg twice per week) also reduces tumor growth in a GXF251L mouse xenograft model.3


1.Mbaveng, A.T., Bitchagno, G.T.M., Kuete, V., et al.Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagyPhytomedicine60152832(2019) 2.Rhee, I.K., Appels, N.M.G.M., Hofte, B., et al.Isolation of the acetylcholinesterase inhibitor ungeremine from Nerine bowdenii by preparative HPLC coupled on-line to a flow assay systemBiol. Pharm. Bull.27(11)1804-1809(2004) 3.Barthelmes, H.U., Niederberger, E., Roth, T., et al.Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cellsBr. J. Cancer85(10)1585-1591(2001) 4.Casu, L., Cottiglia, F., Leonti, M., et al.Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerasesBioorg. Med. Chem. Lett.21(23)7041-7044(2011)