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Ganoderic Acid DM
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ganoderic Acid DM图片
规格:98%
分子量:468.7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Ganoderic acid DM 是一种从灵芝中分离的天然三萜类化合物,可诱导人乳腺癌细胞的 DNA 损伤、G1 细胞周期停滞和凋亡。
货号:ajcx25568
CAS:173075-45-1
分子式:C30H44O4
分子量:468.7
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ganoderic acid DM is a triterpenoid that has been found inG. lucidumand has diverse biological activities.1,2,3It inhibits 5α-reductase and HMG-CoA reductase (IC50s = 10.6 and 9.5 µM, respectively) and binds to the ligand-binding domain of the androgen receptor in a fluorescence polarization assay.1,2Ganoderic acid suppresses osteoclastogenesis of RAW 264.7 cells when used at a concentration of 12.5 µM and is cytotoxic to K562 leukemia and PC3 prostate cancer cells (IC50s = 18.8 and 81.6 µM, respectively). It reduces ear edema induced by phorbol 12-myristate 13-acetate in mice (ID50= 0.08 mg/ear).3


1.Liu, J., Shiono, J., Shimizu, K., et al.Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitorBioorg. Med. Chem. Lett.19(8)2154-2157(2009) 2.Wang, K., Bao, L., Xiong, W., et al.Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α?glucosidaseJ. Nat. Prod.78(8)1977-1989(2015) 3.Akihisa, T., Nakamura, Y., Tagata, M., et al.Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidumChem. Biodivers.4(2)224-231(2007)