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QLT0267
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QLT0267图片
规格:98%
分子量:232.2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An ILK inhibitor
货号:ajcx25410
CAS:866409-68-9
分子式:C10H12N6O
分子量:232.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

QLT0267 is an inhibitor of integrin-linked kinase (ILK; IC50= 26 nM).1It is greater than 10-fold selective for ILK over cyclin-dependent kinase 1 (Cdk1), Cdk2, and Cdk5, as well as greater than 1,000-fold selective for ILK over C-terminal Src kinase (CSK), DNA-PK, Pim-1, Akt, PKC, and casein kinase 2 (CK2), at 10 mg/ml. QLT0267 inhibits the growth of NPA187 papillary thyroid cancer cells (IC50= ~3 µM) and induces apoptosis in NPA187, DRO, and K4 cancer cell lines.In vivo, QLT0267 (100 mg/kg) reduces tumor growth in a DRO mouse xenograft model. It also reduces tumor volume and intratumoral blood vessel mass in a U87MG glioblastoma mouse xenograft model.2


1.Younes, M.N., Kim, S., Yigitbasi, O.G., et al.Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancerMol. Cancer. Ther.4(8)1146-1156(2005) 2.Edwards, L.A., Woo, J., Huxham, L.A., et al.Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK)Mol. Cancer Ther.7(1)59-70(2008)