An inhibitor of late-stage autophagy
货号:ajcx25146
CAS:2130033-55-3
分子式:C30H30O12
分子量：582.6
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PHY34 is an inhibitor of late-stage autophagy.¹It is cytotoxic to OVCAR-3 and OVCAR-8 ovarian cancer cells (IC₅₀= 4 nM for both) and induces apoptosis in the same cells when used at a concentration of 100 nM. PHY34 increases the number of LC3B puncta and induces autophagosome accumulation in HeLa cells (EC₅₀s = 1.99 and 3.86 nM, respectively). It reduces tumor growth in an OVCAR-8 mouse xenograft model when administered at a dose of 0.75 mg/kg.

1.Young, A.N., Herrera, D., Huntsman, A.C., et al.Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high-grade serous ovarian cancer by late-stage autophagy inhibitionMol. Cancer Ther.17(10)2123-2135(2018)