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Loxapine-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loxapine-d8图片
规格:98%
分子量:335.9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of loxapine
货号:ajcx25128
CAS:1189455-63-7
分子式:C18H10ClD8N3O
分子量:335.9
溶解度:Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Loxapine-d8is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic.1It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7(Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.


1.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003)