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Pseudomonic Acid(lithium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pseudomonic Acid(lithium salt)图片
规格:98%
分子量:506.6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
An antibiotic
货号:ajcx25084
CAS:73346-79-9
分子式:C26H43O9·Li
分子量:506.6
溶解度:Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Pseudomonic acid is an antibiotic and bacterial metabolite that has been found inP. fluorescens.1It is bacteriostatic againstS. aureus(MIC = 0.05 µg/ml) and active against skin wound clinical isolates of methicillin-resistantS. aureus(MRSA; MICs = 1-4 µg/ml).2,3Pseudomonic acid inhibits MRSA andP. aeruginosabiofilm formationin vitro.4It inhibits bacterial cell wall isoleucyl-tRNA synthetase, slowing bacterial growth.2,4Topical administration of pseudomonic acid (2% v/v) reduces the number of wound colony forming units (CFUs) in a mouse model of MRSA skin infection.3


1.Fuller, A.T., Mellows, G., Woolford, M., et al.Psuedomonic acid: An antibiotic produced by Pseudomonas fluorescensNature234(5329)416-417(1971) 2.Hughes, J., and Mellows, G.On the mode of action of pseudomonic acid: Inhibition of protein synthesis in Staphylococcus aureusJ. Antibiot. (Tokyo)31(4)330-335(1978) 3.Mohammad, H., Cushman, M., and Seleem, M.N.Antibacterial evaluation of synthetic thiazole compounds in vitro and in vivo in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection mouse modelPLoS One10(11)e0142321(2015) 4.Khoshnood, S., Heidary, M., Asadi, A., et al.A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureusBiomed. Pharmacother.1091809-1818(2019)