您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Phenethyl isothiocyanate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Phenethyl isothiocyanate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenethyl isothiocyanate图片
规格:98%
分子量:163.2
包装与价格:
包装价格(元)
50g电议
100g电议

产品介绍
An isothiocyanate with anticancer activity
货号:ajcx25012
CAS:2257-09-2
分子式:C9H9NS
分子量:163.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Phenethyl isothiocyanate (PEITC) is an isothiocyanate that has been found in cruciferous vegetables and has anticancer activity.1It inhibits the activity of glutathione peroxidase (GPX), reduces cellular glutathione (GSH) levels, and induces the accumulation of reactive oxygen species (ROS) in T72 ovarian epithelial cells expressing H-RasV12when used at a concentration of 10 µM.2PEITC (10 µM) induces cell cycle arrest at the G2/M phase and apoptosis in PL45, MIA PaCa-2, and BxPC-3 pancreatic cancer cells.3It decreases the number of tumor cells expressing Ki-67 or proliferating cell nuclear antigen (PCNA), markers of cell proliferation, and reduces tumor growth in a MIA PaCa-2 mouse xenograft model.


1.Gupta, P., Wright, S.E., Kim, S.-H., et al.Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanismsBiochim. Biophys. Acta1846(2)405-424(2014) 2.Trachootham, D., Zhou, Y., Zhang, H., et al.Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanateCancer Cell10(3)241-252(2006) 3.Stan, S.D., Singh, S.V., Whitcomb, D.C., et al.Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal modelNutr. Cancer66(4)747-755(2014)