Background:

3,4-MDMA-d₅(hydrochloride) (CRM) is a certified reference material that is intended for use as an internal standard for the quantification of 3,4-MDMA by GC- or LC-MS. 3,4-MDMA is also known as ecstasy. It is a euphoric entactogen that is illegal in most countries and is regulated (Schedule I) in the United States.¹It inhibits transporters for noradrenaline and serotonin (IC₅₀s = 6.6 and 34.8 μM, respectively) and blocks the uptake of dopamine (IC₅₀= 0.48 μM).^2,3This product is intended for research and forensic applications.

1.Chakraborty, K., Neogi, R., and Basu, D.Club drugs: Review of the 'rave' with a note of concern for the Indian scenarioIndian J. Med. Res.133594-604(2011) 2.Cozzi, N.V., Sievert, M.K., Shulgin, A.T., et al.Inhibition of plasma membrane monoamine transporters by β-ketoamphetaminesEuropean Journal of Pharmacology381(1)63-69(1999) 3.Montgomery, T., Buon, C., Eibauer, S., et al.Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell linesBritish Journal of Pharmacology1521121-1130(2007)