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Albendazole-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Albendazole-d7图片
规格:98%
分子量:272.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Albendazole-d7 (SKF-62979-d7) 是氘标记的 Albendazole。
货号:ajcx24710
CAS:1287076-43-0
分子式:C12H8D7N3O2S
分子量:272.4
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Albendazole-d7is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms.1It eliminatesTrichostrongylusin the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection withA. suumlarvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50= 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally.2Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole toH. contortusL3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively).3Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.


1.Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D., et al.Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal roundwormsExperientia32(6)702-703(1976) 2.Pourgholami, M.H., Akhter, J., Wang, L., et al.Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: In vitro and in a xenograft model of peritoneal carcinomatosisCancer Chemother. Pharmacol.55(5)425-432(2005) 3.Lacey, E.Mode of action of benzimidazolesParasitol. Today6(4)112-115(1990)