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4-ANPP-13C6(CRM)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-ANPP-13C6(CRM)图片
包装:100ug
规格:98%
市场价:1721元
分子量:286.4

产品介绍
C13[13C]6H24N2
货号:ajcx24666
CAS:N/A
分子式:C13[13C]6H24N2
分子量:286.4
溶解度:
纯度:98%
存储:Store at -20°C
库存:现货

Background:

4-ANPP-13C6(CRM) is a certified reference material intended for use as an internal standard for the quantification of 4-ANPP by GC- or LC-MS. 4-ANPP is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl from N-phenethyl-4-piperidone .1As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl , butyryl fentanyl , furanyl fentanyl , acrylfentanyl , and fentanyl.2,3,4,54-ANPP-13C6is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.


1.Pease, J.P., LePine, A.J., and Smith, C.M.Methods for preparing fentanyl and fentanyl intermediatesPatent Application PublicationUS 2013/0281702 A1(2013) 2.Watanabe, S., Vikingsson, S., Roman, M., et al.In vitro and in vivo metabolite identification studies for the new synthetic opioids acetylfentanyl, acrylfentanyl, furanylfentanyl, and 4-fluoro-isobutyrylfentanylAAPS J.19(4)1102-1122(2017) 3.Labroo, R.B., Paine, M.F., Thummel, K.E., et al.Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: Implications for interindividual variability in disposition, efficacy, and drug interactionsDrug Metab. Dispos.25(9)1072-1079(1997) 4.Melent'ev, A.B., Kataev, S.S., and Dvorskaya, O.N.Identification and analytical properties of acetyl fentanyl metabolitesJ. Anal. Chem.70(2)216-224(2015) 5.Steuer, A.E., Williner, E., Staeheli, S.N., et al.Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS)Drug Test Anal.9(7)1085-1092(2017)