| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 7779元 |
| 分子量: | 427.4 |
Background:
Vanoxonin is a bacterial metabolite that has been found inS. hirsuta.1It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50value of 0.7 µg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 µg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.
1.Kanai, F., Sawa, T., Hamada, M., et al.Vanoxonin, a new inhibitor of thymidylate synthetaseJ. Antibiot. (Tokyo)36(6)656-660(1983)
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