A bacterial metabolite with diverse biological activities
货号:ajcx23944
CAS:178182-49-5
分子式:C33H30O17
分子量：698.6
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.¹It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs =<0.05-0.39 µg/ml). Heliquinomycin inhibits the activity of DNA helicase with a K_ivalue of 6.8 µM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC₅₀s = 0.97, 0.89, and 0.83 µg/ml, respectively).

1.Chino, M., Nishikawa, K., Umekita, M., et al.Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)49(8)752-757(1996)