A mixture of N-glycolyl-ganglioside GM3
货号:ajcx23844
CAS:69345-49-9
分子式:C64H117N2O22•NH4 (for tricosanoyl)
分子量：1284.7
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-glycolyl-Ganglioside G_M3(NeuGc-GM3) is a form of ganglioside G_M3that contains an N-glycolylated sialic acid (NeuGc). It is not biosynthesized in humans under baseline conditions due to a mutation in CMP-Neu5Ac hydroxylase (CMAH), which converts N-acetyl sialic acid to N-glycolyl sialic acid, but NeuGc can be taken up by human cellsviathe diet and incorporated into glycolipids, such as ganglioside G_M3.^1,2NeuGc-GM3 impairs differentiation and maturation of dendritic cellsin vitroand reduces CD4 expression in non-activated T cells.^1,3It increases the number of lung tumor nodules formed in a murine Lewis lung carcinoma model.⁴It is found in a variety of human cancers, including breast and lung cancers, as well as pediatric cancers.¹Levels of NeuGc-GM3 are negatively correlated with the number of mature dendritic cells in patient-derived non-small cell lung cancer (NSCLC) tumor tissue.⁵Anti-NeuGc-GM3 antibodies, able to destroy tumor cellsin vitro, have been found in individuals without cancer but not in patients with NSCLC.^1,6N-glycolyl-Ganglioside G_M3mixture contains ganglioside G_M3molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1553]

1.Labrada, M., Dorvignit, D., Hevia, G., et al.GM3(Neu5Gc) ganglioside: An evolution fixed neoantigen for cancer immunotherapySemin. Oncol.45(1-2)41-51(2018) 2.Tangvoranuntakul, P., Gagneux, P., Diaz, S., et al.Human uptake and incorporation of an immunogenic nonhuman dietary sialic acidProc. Natl. Acad. Sci. USA100(21)12045-12050(2003) 3.de LeÓn, J., FernÁndez, A., Clavell, M., et al.Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells functionInt. Immunol.20(4)591-600(2008) 4.Segatori, V.I., Vazquez, A.M., Gomez, D.E., et al.Preclinical evaluation of racotumomab, an anti-idiotype monoclonal antibody to N-glycolyl-containing gangliosides, with or without chemotherapy in a mouse model of non-small cell lung cancerFront. Oncol.2160(2012) 5.van Cruijsen, H., Ruiz, M.G., van der Valk, P., et al.Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancerBMC Cancer9180(2009) 6.RodrÍguez-Zhurbenko, N., MartÍnez, D., Blanco, R., et al.Human antibodies reactive to NeuGcGM3 ganglioside have cytotoxic antitumor propertiesEur. J. Immunol.43(3)826-837(2013)