| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 1871元 |
| 分子量: | 844.9 |
Background:
Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 µg/ml, respectively).1
1.Henkel, T., Ciesiolka, T., Rohr, J., et al.Urdamycins, new angucycline antibiotics from Streptomyces fradiae. V. Derivatives of urdamycin AJ. Antibiot. (Tokyo)42(2)299-311(1989) 2.Drautz, H., ZÄhner, H., Rohr, J., et al.Metabolic products of microorganisms. 234. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. I. Isolation, characterization and biological propertiesJ. Antibiot. (Tokyo)39(12)1657-1669(1986)
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